Dr. Shoib Siddiqui is a senior lecturer in the School of Life and Medical Sciences at the University of Hertfordshire, UK. He joined the
University of Hertfordshire (UH) in January 2021. He has done a master’s in biotechnology from IIT-Bombay, India and Ph.D. from ETH
Zurich, Switzerland, in the field of pharmacogenomics under Prof. Michael Detmar. In his Ph.D., he investigated the role of neuropilin-2
(Nrp2) in skin inflammation and melanoma progression. Shoib did his postdoctoral research in the lab of Prof. Ajit Varki at the University of
California, San Diego (UCSD), USA.
Driven by his keen interest in academia, he joined the American University of Ras Al Khaimah (AURAK), UAE, as an Assistant Professor
in 2018 and have gained two years of strong teaching experience in courses named General Microbiology, Applied and Industrial
Microbiology, Research Methodology, Cell Culture, Food Biotechnology, Immunology and Senior project.
Several research articles bagged him accolades from reputed media channels. His research article entitled “Engagement of
Myelomonocytic Siglecs by Tumor-associated Ligands Modulates the Innate Immune Response to Cancer,” published in PNAS 2014, was
highlighted in major news articles worldwide. The paper entitled “Self-associated molecular patterns mediate cancer immune evasion by
engaging Siglecs on T cells” published in the “JCI” in 2018 was featured in the news magazine "Scientific American" under the title “The
Biology of Sugars Points to a Sweet Strategy for Treating Cancer”. The recent paper on Siglec-12 entitled “Human-specific polymorphic
pseudogenization of SIGLEC12 protects against advanced cancer progression” was highlighted by26 news outlets worldwide.
Having been closely associated with Science for a humongous period of time, he has attained extensive experience and practical knowledge
of the field. In the last ten years of his scientific career, he has presented his research work at many conferences in different countries.
Collaborators and Co-authors
The interest of Shoib’s lab is mainly focused on deciphering the role of the Siglec-Sia axis in cancer and other pathological conditions. Siglecs (sialic-acid-binding immunoglobulin-like lectins) are expressed mainly by the immune cells and play a vital role in immune regulation. The lab is trying to understand the gene regulation of Siglecs, the polarization of immune cells by Siglecs and further targeting of Siglec-Sia in the cancer microenvironment.
1. Siddiqui SS, Vaill M, Varki A (2021). Ongoing Selection for a uniquely human null allele of SIGLEC12 in world‐wide populations may protect against risk of advanced carcinomas. FASEB BioAdvances, 3 (4), 278-279.
2. Siddiqui SS*, Dhar C*, Sundaramurthy V, Sasmal A, Yu H, Bandala-Sanchez E, Li M, Zhang X, Chen X, Harrison LC, Xu D, Varki A (2021). Sialoglycan Recognition is a Common Connection Linking Acidosis, Zinc and HMGB1 in Sepsis. Proc Natl Acad Sci U.S.A (PNAS), 118(10):e2018090118 . (IF-11.205).
3. Hodeify R, Siddiqui SS, Matar R, Vazhappilly CG, Merheb M, Al Zouabi H, Marton H (2021). Modulation of calcium-binding proteins expression and cisplatin chemosensitivity by calcium chelation in human breast cancer MCF-7 cells. Heliyon. 7 (1), e06041.
4. Kawanishi K, Saha S, Diaz S, Vaill M, Sasmal A, Siddiqui SS, Choudhury BP, Sharma K, Chen X, Schoenhofen IC, Sato C, Kitajima K, Freeze HH, Münster-Kühnel A, Varki A (2020). Evolutionary conservation of human ketodeoxynonulosonic acid production is independent of sialoglycan biosynthesis. Journal of Clinical Investigation (JCI). 131(5):e137681. (IF- 14.808).
5. Siddiqui SS, Vaill M, Do R, Khan N, Verhagen AL, Zhang W, Lenz HJ, Johnson‐Pais TL, Leach RJ, Fraser G, Wang C, Feng GS, Varki N, Varki A (2020). Human‐specific polymorphic pseudogenization of SIGLEC12 protects against advanced cancer progression. FASEB Bioadvances. 3 (2), 69-82. (Cover of the Journal)
6. Vazhappilly CG, Hodeify R, Siddiqui SS, Laham AJ, Menon V, El‐Awady R, Matar R, Merheb M, Marton J, Al Zouabi HAK, Radhakrishnan R (2020). Natural compound catechol induces DNA damage, apoptosis, and G1 cell cycle arrest in breast cancer cells. Phytotherapy Research. 35 (4), 2185-2199. (IF- 5.878).
7. Läubli H, Kawanishi K, Vazhappilly CG, Matar R, Merheb M, Siddiqui SS* (2020). Tools to study and target the Siglec–sialic acid axis in cancer. FEBS Journal. (*Corresponding author). (IF- 5.542).
8. Siddiqui SS, Rahman S, Rupasinghe HP, Vazhappilly CG (2020) Dietary Flavonoids in p53—Mediated Immune Dysfunctions Linking to Cancer Prevention. Biomedicines 8 (8), 286 (IF- 6.081).
9. Siddiqui SS*, Matar R, Merheb M, Hodeify R, Vazhappilly CG, Marton J, Shamsuddin SA, Zouabi HA (2019). Siglecs in brain function and neurological disorders. Cells, 8, 1125 (*Corresponding author). (IF- 6.600)
10. Saha S, Siddiqui SS, Khan N, Verhagen A, Jiang W, Springer S, Ghosh P, Varki A (2019). Controversies about the subcellular localization and mechanisms of action of the Alzheimer’s disease-protective CD33 splice variant. Acta Neuropathologica. 138(4):671-2. (IF- 17.088)
11. Vazhappilly CG, Ansari SA, Al-Jaleeli R, Al-Azawi AM, Ramadan WS, Menon V, Hodeify R, Siddiqui SS, Merheb M, Matar R, Radhakrishnan R (2019). Role of Flavonoids in Thrombotic, Cardiovascular, and Inflammatory Diseases. Inflammopharmacology. 27 (5), 863-869. (IF- 4.473)
12. Merheb M, Matar R, Hodeify R, Siddiqui SS, Vazhappilly CG, Marton J, Syed A, Zouabi HAL (2019). Mitochondrial DNA, a Powerful tool to Decipher Ancient Human Civilization from Domestication to Music and to Uncover Historical Murder Cases. Cells, 8, 433. (IF-6.600)
13. Uchiyama, S, Sun, J, Fukahori, K, Ando, N, Wu, M, Schwarz, F, Siddiqui, SS, Varki, A, Marth, J, Nizet, V (2019). Dual Actions of Group B Streptococcus Capsular Sialic Acid Provide Resistance to Platelet-Mediated Antimicrobial Killing. Proc Natl Acad Sci U.S.A. (PNAS), 116: 7465-7470. (IF- 11.205)
14. Stanczak*, M.A., Siddiqui*, S.S., Trefny, M.P., Thommen, D.S., Boligan, K.F., von Gunten, S., Tzankov, A., Tietze, L., Lardinois, D., Heinzelmann-Schwarz, V., von Bergwelt-Baildon, M.S., Zhang, W., Lenz, H.J., Han, Y., Amos, C.I., Syedbasha, M., Egli, A., Stenner, F., Speiser, D.E., Varki, A., Zippelius, A., and Läubli, H (2018). Self-associated molecular patterns mediate cancer immune evasion by engaging Siglecs on T cells. (*equal contribution). Journal of Clinical Investigation (JCI) 128:4912-4923. (IF- 14.808)
15. Siddiqui SS, Springer SA, Verhagen A, Sundaramurthy V, Alisson-Silva F, Jiang
W, Ghosh P and Varki A (2017). The Alzheimer’s Disease–protective CD33 Splice Variant Mediates Adaptive Loss of Function via Diversion to an Intracellular Pool. J Biol Chem, 292:15312-15320. (IF- 5.157)
16. Schwarz F., Landig CS, Siddiqui SS, Secundino I, Olson J, Varki N, Nizet V and Varki A (2017). Paired Siglec receptors generate opposite inflammatory responses to a human-specific pathogen. EMBO J, 36, 751-760. (IF- 11.598).
17. Siddiqui S, Schwarz F, Springer S, Khedri Z, Yu H, Deng L, Verhagen A, Jiang W, Kim D, Zhou J, Naito-Matsui Y, Chen X, Varki N and Varki A (2017). New findings on the detection, expression, dimerization and ligand binding properties of mouse Siglec-E. J Biol Chem, 292, 1029-1037. (IF- 5.157)
18. Läubli, H., da Silva, F.A., Stanczak, M.A., Siddiqui, SS, Deng, L., Verhagen, A., Varki, N., Varki, A. (2014): Lectin galactoside-binding soluble 3 binding protein (LGALS3BP) is a tumor-associated immunomodulatory ligand for CD33-related Siglecs. J Biol Chem, 289:33481-33491. (IF- 5.157)
19. Läubli, H., Pearce, O.M.T., Schwarz, F., Siddiqui, SS, Deng, L., Stanczak, M., Deng, L., Verhagen, A., Secrest, P., Lusk, C., Schwartz, A.G., Varki, N., Bui, J.D., Varki, A. (2014): Engagement of Myelomonocytic Siglecs by Tumor-associated Ligands Modulates the Innate Immune Response to Cancer. Proc Natl Acad Sci U.S.A (PNAS)., 111:14211-14216. (IF- 11.205).
20. Jurisic G*, Maby-El Hajjami H*, Karaman S, Ochsenbein AM, Alitalo A, Siddiqui SS, Ochoa Pereira C, Petrova TV, Detmar M. (2012): An unexpected role of semaphorin 3A/neuropilin-1 signaling in lymphatic vessel maturation and valve formation. Circulation Research, 111: 426-36. (IF- 17.367).
21. Huggenberger R, Siddiqui SS, Brander D, Ullmann S, Zimmermann K, Antsiferova M, Werner S, Alitalo K, Detmar M. (2011): An important role of lymphatic vessel activation in limiting acute inflammation. Blood, 117: 4667-78. (IF- 22.113).
1. Varki A, Varki N, Verhagen A, Siddiqui S.. Method and device for detecting Siglec12 (2020), US Patent App. 16/552,876.
Published papers in conference proceedings
Polymorphic Pseudogenization of SIGLEC12 in Humans: Relationship to Late Stage Cancer Progression. (2018). SS Siddiqui, R Do, W Zhang, HJ Lenz, T Johnson‐Pais, R Leach, G Fraser, CWang, N Varki, A Varki.
The FASEB Journal. Vol 32. Page. 673.12-673.12.
Upregulation of self-associated molecular patterns and Siglec receptors on T cells facilitate cancer immune evasion. (2016). MA Stanczak, S Siddiqui, A Varki, A Zippelius, H Läubli.
Annals of Oncology. Vol. 27. Page viii5-viii6
Truncated isoform of CD33 encoded by Alzheimer's disease protective allele is selectively diverted into an intracellular pool (2016). S S Siddiqui, A L Verhagen, V Sundaramurthy, F Alisson-Silva, S Diaz, N Varki, P Ghosh, A Varki.
. Vol 26, Page 1440-1440.
New findings on the detection, expression, dimerization and ligand binding properties of mouse Siglec-E (2015). S S Siddiqui, F Schwarz, S Springer, Z Khedri, H Yu, L Deng, A Verhagen, W Jiang, D Kim, J Zhou, Y Naito-Matsui, X Chen, N Varki, A Varki.
GLYCOBIOLOGY. Vol. 25, Page 1255-1255.
Lymphatic endothelium-derived chemokines CXCL10 and 11 promote expansion of human melanoma stem cells (2013). K Shiraishi, Y Chen, S S Siddiqui, S Higashiyama, K Sayama, S Hirakawa, M Detmar.
Journal of Investigative Dermatology. Vol. 133, Page S243-S243
Differential effects of glucocorticoid treatment on inflammatory changes of cutaneous lymphatic and blood vessels (2011). R Huggenberger, K Messmer, S S Siddiqui, M M Schulz, M Detmar.
Journal of Investigative Dermatology. Vol 131, Page S31-S31